Fluticasone propionate (FP) is most often used for the treatment of several skin disorders due to its anti-inflammatory and anti proliferative effect. The aim of the present study was to formulate hydrogel of FP using combination of carbopol 934 and HPMC K4M in different concentration of 0.5, 0.75 and 1% (w/w). FP hydrogel formulations (G1-G9) were evaluated for pH, viscosity, spreadability, drug content, ex-vivo diffusion study and skin irritation study. The spreadability of G1-G9 was found in the range of 4.6-6 cm/s indicating good spreadability. The drug content of G1-G9 was found in the range of 91.4-95.7%. Cumulative % drug release of G1-G9 was in the range of 29.23-26.83%. FP hydrgel (G9) containing 1% carbopol 934 and 1% HPMC K4M showed 26.83% diffusion indicating sustained release of FP as compared to other batches. From skin irritation study it was revealed that as none of the hydrogel formulation resulted into skin irritation, FP hydrogel can be easily accepted for topical application. FP hydrogel due to sustained drug release and non irritation can be used for the treatment of several skin disorders.
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